Case‐Control study of dopamine transporter‐1, monoamine oxidase‐B, and catechol‐O‐methyl transferase polymorphisms in Parkinson's disease
Identifieur interne : 004548 ( Main/Exploration ); précédent : 004547; suivant : 004549Case‐Control study of dopamine transporter‐1, monoamine oxidase‐B, and catechol‐O‐methyl transferase polymorphisms in Parkinson's disease
Auteurs : John L. Goudreau [États-Unis] ; Demetrius M. Maraganore [États-Unis] ; Matthew J. Farrer [États-Unis] ; Timothy G. Lesnick [États-Unis] ; Andrew B. Singleton [États-Unis] ; James H. Bower [États-Unis] ; John A. Hardy [États-Unis] ; Walter A. Rocca [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2002-11.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Adult, Age Factors, Aged, Aged, 80 and over, Amine oxidase (flavin-containing), Biological transport, COMT, Case control study, Case-Control Studies, Catechol O-Methyltransferase (genetics), Catechol O-methyltransferase, DAT1, Dopamine, Dopamine Plasma Membrane Transport Proteins, Exploration, Female, Genetics, Genotype, Human, Humans, Likelihood Functions, MAO‐B, Male, Membrane Glycoproteins, Membrane Transport Proteins (genetics), Middle Aged, Midwestern United States, Minisatellite Repeats (genetics), Monoamine Oxidase (genetics), Nerve Tissue Proteins, Parkinson Disease (diagnosis), Parkinson Disease (genetics), Parkinson disease, Parkinson's disease, Polymorphism, Polymorphism, Genetic (genetics), Regression Analysis, Sex Factors, case‐control study, polymorphisms, susceptibility genes.
- MESH :
- chemical , genetics : Catechol O-Methyltransferase, Membrane Transport Proteins, Monoamine Oxidase.
- geographic : Midwestern United States, Nerve Tissue Proteins.
- diagnosis : Parkinson Disease.
- genetics : Minisatellite Repeats, Parkinson Disease, Polymorphism, Genetic.
- Adult, Age Factors, Aged, Aged, 80 and over, Case-Control Studies, Dopamine Plasma Membrane Transport Proteins, Female, Humans, Likelihood Functions, Male, Membrane Glycoproteins, Middle Aged, Regression Analysis, Sex Factors.
Abstract
We investigated the association of Parkinson's disease (PD) with dopamine transporter‐1 (DAT1), monoamine oxidase‐B (MAO‐B), and catechol‐O‐methyltransferase (COMT) gene polymorphisms. Overall, we observed no significant association of PD with the DAT1‐3′–variable numbers of tandem repeats, the MAO‐B‐(GT)n, and the COMT‐Val108Met gene polymorphisms in a sample of 319 unrelated PD cases and 196 control subjects. Analyses stratified by sex, age at examination, family history of PD, and ethnic origin also yielded negative findings, with three exceptions. We found statistically significant associations of PD with MAO‐B polymorphisms in older patients and with a COMT polymorphism in younger subjects and in women. These significant differences at the two‐tailed alpha level of 0.05 and restricted to subgroup analyses may have a biological basis or may be chance findings. © 2002 Movement Disorder Society
Url:
DOI: 10.1002/mds.10268
Affiliations:
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Goudreau</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurogenetics Laboratory, Department of Neuroscience, Mayo Clinic and Mayo Foundation, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Lesnick, Timothy G" sort="Lesnick, Timothy G" uniqKey="Lesnick T" first="Timothy G." last="Lesnick">Timothy G. Lesnick</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Singleton, Andrew B" sort="Singleton, Andrew B" uniqKey="Singleton A" first="Andrew B." last="Singleton">Andrew B. 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2002-11">2002-11</date><biblScope unit="vol">17</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1305">1305</biblScope><biblScope unit="page" to="1311">1311</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">17E4A865A2CDE279A9BE0325ECB6D6011FD31CD4</idno><idno type="DOI">10.1002/mds.10268</idno><idno type="ArticleID">MDS10268</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Amine oxidase (flavin-containing)</term><term>Biological transport</term><term>COMT</term><term>Case control study</term><term>Case-Control Studies</term><term>Catechol O-Methyltransferase (genetics)</term><term>Catechol O-methyltransferase</term><term>DAT1</term><term>Dopamine</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Exploration</term><term>Female</term><term>Genetics</term><term>Genotype</term><term>Human</term><term>Humans</term><term>Likelihood Functions</term><term>MAO‐B</term><term>Male</term><term>Membrane Glycoproteins</term><term>Membrane Transport Proteins (genetics)</term><term>Middle Aged</term><term>Midwestern United States</term><term>Minisatellite Repeats (genetics)</term><term>Monoamine Oxidase (genetics)</term><term>Nerve Tissue Proteins</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (genetics)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Polymorphism</term><term>Polymorphism, Genetic (genetics)</term><term>Regression Analysis</term><term>Sex Factors</term><term>case‐control study</term><term>polymorphisms</term><term>susceptibility genes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Catechol O-Methyltransferase</term><term>Membrane Transport Proteins</term><term>Monoamine Oxidase</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Midwestern United States</term><term>Nerve Tissue Proteins</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Minisatellite Repeats</term><term>Parkinson Disease</term><term>Polymorphism, Genetic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Female</term><term>Humans</term><term>Likelihood Functions</term><term>Male</term><term>Membrane Glycoproteins</term><term>Middle Aged</term><term>Regression Analysis</term><term>Sex Factors</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Amine oxidase (flavin-containing)</term><term>Catechol O-methyltransferase</term><term>Dopamine</term><term>Etude cas témoin</term><term>Exploration</term><term>Génotype</term><term>Génétique</term><term>Homme</term><term>Parkinson maladie</term><term>Polymorphisme</term><term>Transport biologique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated the association of Parkinson's disease (PD) with dopamine transporter‐1 (DAT1), monoamine oxidase‐B (MAO‐B), and catechol‐O‐methyltransferase (COMT) gene polymorphisms. Overall, we observed no significant association of PD with the DAT1‐3′–variable numbers of tandem repeats, the MAO‐B‐(GT)n, and the COMT‐Val108Met gene polymorphisms in a sample of 319 unrelated PD cases and 196 control subjects. Analyses stratified by sex, age at examination, family history of PD, and ethnic origin also yielded negative findings, with three exceptions. We found statistically significant associations of PD with MAO‐B polymorphisms in older patients and with a COMT polymorphism in younger subjects and in women. These significant differences at the two‐tailed alpha level of 0.05 and restricted to subgroup analyses may have a biological basis or may be chance findings. © 2002 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li><li>Minnesota</li></region></list><tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Goudreau, John L" sort="Goudreau, John L" uniqKey="Goudreau J" first="John L." last="Goudreau">John L. Goudreau</name></region><name sortKey="Bower, James H" sort="Bower, James H" uniqKey="Bower J" first="James H." last="Bower">James H. Bower</name><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><name sortKey="Hardy, John A" sort="Hardy, John A" uniqKey="Hardy J" first="John A." last="Hardy">John A. Hardy</name><name sortKey="Lesnick, Timothy G" sort="Lesnick, Timothy G" uniqKey="Lesnick T" first="Timothy G." last="Lesnick">Timothy G. Lesnick</name><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A." last="Rocca">Walter A. Rocca</name><name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A." last="Rocca">Walter A. Rocca</name><name sortKey="Singleton, Andrew B" sort="Singleton, Andrew B" uniqKey="Singleton A" first="Andrew B." last="Singleton">Andrew B. Singleton</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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